Hypocretin/orexin deficiency decreases cocaine abuse liability
نویسندگان
چکیده
منابع مشابه
Abuse Liability of Baclofen
TO THE EDITOR I read with interest the case report on baclofen abuse by Ghosh and Bhuyan in May issue of Clinincal Psychopharmacology and Neuroscience 2017. The patient reportedly was prescribed quetiapine 100 mg, escitalopram 20 mg, mirtazapine 15 mg, lorazepam 2 mg and baclofen 20 mg after initial detoxification, for depression and insomnia along with relapse prevention. As mentioned, escital...
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Aminorex is a cyclic phenylisopropylamine that has been marketed as an anorectic. Despite obvious pharmacological similarities to the amphetamines, little is known about its liability for abuse. In the present study, one group of rhesus monkeys (n = 3) was prepared with intravenous catheters and allowed to self-administer either methohexital or saline in daily experimental sessions. When methoh...
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The abuse liability profile of three synthetic hallucinogens, N,N-diisopropyltryptamine (DIPT), 5-N,N-diethyl-5-methoxytryptamine (5-MeO-DET), and 5-methoxy-α-methyltryptamine (5-MeO-AMT), was tested in rats trained to discriminate hallucinogenic and psychostimulant compounds, including cocaine, methamphetamine, 3,4-methylenedioxymethylamphetamine (MDMA), lysergic acid diethylamide (LSD), (-)-2...
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It is consensually accepted that the liability for developing a substance abuse disorder is not the same for all individuals in the population. Only marginal progress has been made, however, in determining the factors responsible for the variation in the liability to drug abuse, encompassing interacting biological, behavioral, and environmental processes. Since variation in the liability has a ...
متن کاملAbuse liability of diazepam through different routes.
Abuse liability of diazepam was examined among experienced drug users. The subjects, randomly divided into two groups, each having eight subjects, received diazepam, 15 mg intravenously (gr. 1) and 30 mg orally (gr. 2). Subjective states, drug liking, sedation and euphoria were assessed at pre-drug, 15 min, 120 min and 240 min post-drug administration. In addition, brief assessment to evaluate ...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2018
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2018.02.010